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Venlafaxine Hydrochloride

VENLAFAXINE HYDROCHLORIDE

Manufacturer: A-S Medication Solutions

Score: 144.0

Quick Summary

Venlafaxine Hydrochloride is a serotonin and norepinephrine reuptake inhibitor (SNRI) used for the treatment of Major Depressive Disorder (MDD), Generalized Anxiety Disorder (GAD), Social Anxiety Disorder (SAD), and Panic Disorder (PD). The recommended starting dose is 75 mg per day, administered in a single dose, with a maximum dose of 225 mg per day. It is essential to monitor patients for clinical worsening, suicidal thoughts, and behaviors, especially during the initial few months of treatment or when the dose is changed. The drug has several contraindications, including hypersensitivity to venlafaxine hydrochloride, and use with monoamine oxidase inhibitors (MAOIs). Special population considerations, such as use during pregnancy, nursing mothers, pediatric use, and geriatric use, are also crucial to ensure safe and effective treatment.

Key Clinical Findings and Indications

  • Major Depressive Disorder (MDD)
  • Generalized Anxiety Disorder (GAD)
  • Social Anxiety Disorder (SAD)
  • Panic Disorder (PD)

Important Safety Information

Warning

Increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults

Contraindications

  • Hypersensitivity to venlafaxine hydrochloride
  • Use with monoamine oxidase inhibitors (MAOIs)

Adverse Reactions

  • Nausea
  • Somnolence
  • Dry mouth
  • Sweating
  • Abnormal ejaculation
  • Anorexia
  • Constipation
  • Erectile dysfunction
  • Libido decreased

Dosing Recommendations

General Guidance

Dose adjustments may be necessary in patients with renal or hepatic impairment

MDD

Adult Dose

75 mg per day

Pediatric Dose

Not recommended

GAD

Adult Dose

75 mg per day

Pediatric Dose

Not recommended

SAD

Adult Dose

75 mg per day

Pediatric Dose

Not recommended

PD

Adult Dose

37.5 mg per day

Pediatric Dose

Not recommended

Special Population Considerations

Pregnancy

  • Use during pregnancy only if the potential benefit justifies the potential risk to the fetus

Nursing Mothers

  • Venlafaxine and ODV have been reported to be excreted in human milk

Pediatric Use

  • Not recommended for pediatric patients due to lack of efficacy and potential adverse effects

Geriatric Use

  • No overall differences in effectiveness or safety were observed between geriatric patients and younger patients

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