DULOXETIN HYDROCHLORIDE
Manufacturer: Proficient Rx LP
Score: 148.0
Duloxetine hydrochloride is a selective serotonin and norepinephrine reuptake inhibitor (SSNRI) used for the treatment of major depressive disorder (MDD), generalized anxiety disorder (GAD), diabetic peripheral neuropathic pain (DPNP), chronic musculoskeletal pain, and fibromyalgia. The drug has a boxed warning for increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults. Important safety information includes contraindications with monoamine oxidase inhibitors (MAOIs), potential for serotonin syndrome, and increased risk of bleeding. The recommended dosage varies by condition, with initial dosing and titration ranging from 30 mg to 60 mg per day. Special population considerations include use during pregnancy, nursing mothers, pediatric use, and geriatric use, with specific warnings and precautions for each group.
Increased risk of suicidal thoughts and behaviors in children, adolescents, and young adults
Dose adjustments may be necessary for patients with hepatic or renal impairment
40 mg/day to 60 mg/day
Not established
60 mg/day
Not established
60 mg/day
Not established
30 mg/day to 60 mg/day
Not established