VILAZODONE HYDROCHLORIDE

Manufacturer: Alembic Pharmaceuticals Limited

Score: 144.0

Quick Summary

Vilazodone Hydrochloride is a selective serotonin reuptake inhibitor and 5HT 1A receptor partial agonist used for the treatment of major depressive disorder in adults. The recommended target dosage is 20 mg to 40 mg once daily with food, with a gradual titration and dosing adjustments based on clinical response and patient characteristics. Important safety considerations include the risk of suicidal thoughts and behaviors, serotonin syndrome, increased risk of bleeding, and discontinuation syndrome. The drug has specific contraindications, including concomitant use of monoamine oxidase inhibitors, and requires careful consideration in special populations such as pregnant women, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

Treatment of major depressive disorder in adults
Selective serotonin reuptake inhibitor and 5HT 1A receptor partial agonist
Recommended target dosage: 20 mg to 40 mg once daily with food

Important Safety Information

Warning

Suicidal thoughts and behaviors, serotonin syndrome, increased risk of bleeding, and discontinuation syndrome

Contraindications

Concomitant use of monoamine oxidase inhibitors
Use within 14 days of stopping monoamine oxidase inhibitors

Adverse Reactions

Diarrhea
Nausea
Vomiting
Insomnia
Abnormal dreams
Restlessness

Dosing Recommendations

General Guidance

Dose adjustments may be necessary based on clinical response, patient characteristics, and concomitant use of other medications, including strong CYP3A4 inhibitors or inducers

Major depressive disorder

Adult Dose

Start with 10 mg once daily for 7 days, then increase to 20 mg once daily, and may be increased up to 40 mg once daily after a minimum of 7 days between dosage increases

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

Use during pregnancy may increase the risk of postpartum hemorrhage
Exposure to SSRIs in late pregnancy may increase the risk of neonatal complications

Nursing Mothers

Vilazodone is excreted in human milk, and caution should be exercised when administering to nursing women

Pediatric Use

The safety and effectiveness of vilazodone have not been established in pediatric patients
Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric patients

Geriatric Use

No dosage adjustment is recommended based on age
Geriatric patients may be at greater risk for hyponatremia

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