Tranylcypromine

TRANYLCYPROMINE

Manufacturer: Novitium Pharma LLC

Score: 141.0

Quick Summary

Tranylcypromine is a monoamine oxidase inhibitor (MAOI) used for the treatment of major depressive disorder (MDD) in adult patients who have not responded adequately to other antidepressants. The recommended daily dosage is 30 mg in divided doses, with a maximum dosage of 60 mg per day. Tranylcypromine has several important safety considerations, including the risk of suicidal thoughts and behaviors, hypertensive crisis, and serotonin syndrome. It is contraindicated with several medications and foods, and special populations such as pregnant women, pediatric patients, and geriatric patients require careful consideration.

Key Clinical Findings and Indications

Treatment of major depressive disorder (MDD) in adult patients
Non-hydrazine MAOI
Indicated for patients who have not responded adequately to other antidepressants

Important Safety Information

Warning

Increased risk of suicidal thoughts and behavior in pediatric and young adult patients, and risk of hypertensive crisis with significant tyramine use

Contraindications

Concomitant use or use in rapid succession with other MAOIs, selective serotonin reuptake inhibitors, serotonin and norepinephrine reuptake inhibitors, tricyclic antidepressants, sympathomimetic drugs, and numerous other drugs
Pheochromocytoma or other catecholamine-releasing paragangliomas

Adverse Reactions

Suicidal thoughts and behaviors
Hypertensive crisis
Serotonin syndrome
Dry mouth
Dizziness
Insomnia
Sedation
Headache

Dosing Recommendations

General Guidance

Dosage increases should be made more gradually in patients at risk for hypotension

Major depressive disorder (MDD)

Adult Dose

30 mg per day in divided doses, with a maximum dosage of 60 mg per day

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

There are limited published reports of placental infarction and congenital anomalies in association with use of tranylcypromine during pregnancy

Nursing Mothers

Pediatric Use

Safety and effectiveness of tranylcypromine in the pediatric population have not been established

Geriatric Use

Older patients may be at greater risk of postural hypotension and other serious adverse reactions

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