Home About

Alogliptin and Pioglitazone

ALOGLIPTIN BENZOATE AND PIOGLITAZONE HYDROCHLORIDE

Manufacturer: Padagis Israel Pharmaceuticals Ltd

Score: 144.0

Quick Summary

Alogliptin and Pioglitazone is a combination drug used for the treatment of type 2 diabetes mellitus. It combines alogliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and pioglitazone, a thiazolidinedione. The drug is used as an adjunct to diet and exercise to improve glycemic control. Key clinical findings indicate its efficacy in reducing HbA1c levels and improving insulin sensitivity. Important safety information includes warnings about congestive heart failure, pancreatitis, hypersensitivity reactions, and hepatic effects. The recommended starting dose is individualized based on current regimen and medical condition, with a maximum daily dose of 25 mg of alogliptin and 45 mg of pioglitazone. Special population considerations include use in pregnancy, pediatric and geriatric populations, with specific recommendations for dosing adjustments and monitoring.

Key Clinical Findings and Indications

  • Treatment of type 2 diabetes mellitus
  • Improvement of glycemic control
  • Reduction of HbA1c levels
  • Improvement of insulin sensitivity

Important Safety Information

Warning

Congestive heart failure, pancreatitis, hypersensitivity reactions, and hepatic effects

Contraindications

  • Established NYHA Class III or IV heart failure
  • History of serious hypersensitivity reaction to alogliptin, pioglitazone, or any of the excipients

Adverse Reactions

  • Hypoglycemia
  • Weight gain
  • Edema
  • Fractures
  • Urinary bladder tumors

Dosing Recommendations

General Guidance

Renal impairment: 12.5 mg/30 mg once daily for moderate impairment; not recommended for severe impairment or ESRD. Congestive heart failure: starting dose of 25 mg/15 mg

Type 2 diabetes mellitus

Adult Dose

Individualized based on current regimen and medical condition, with a maximum daily dose of 25 mg of alogliptin and 45 mg of pioglitazone

Pediatric Dose

Special Population Considerations

Pregnancy

  • Limited data available
  • Use with caution

Nursing Mothers

  • Not recommended

Pediatric Use

  • Not recommended

Geriatric Use

  • No overall differences in safety or effectiveness observed between patients 65 years of age and older and younger adult patients

Similar Drugs

Pioglitazole and metformin hydrochloride

PIOGLITAZOLE AND METFORMIN HYDROCHLORIDE

Macleods Pharmaceuticals Limited

Similarity: 83.6%

Pioglitazone Hydrochloride and Metformin Hydrochloride

PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE

AvKARE

Similarity: 80.6%

Pioglitazone Hydrochloride and Metformin Hydrochloride

PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE

Aurobindo Pharma Limited

Similarity: 80.6%

Pioglitazone Hydrochloride and Metformin Hydrochloride

PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE

Rising Pharma Holdings, Inc.

Similarity: 80.6%

Pioglitazone

PIOGLITAZONE

Aphena Pharma Solutions - Tennessee, LLC

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

A-S Medication Solutions

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

A-S Medication Solutions

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

Preferred Pharmaceuticals, Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

Coupler LLC

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

A-S Medication Solutions

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

NuCare Pharmaceuticals,Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

NuCare Pharmaceuticals,Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

NuCare Pharmaceuticals,Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

Bryant Ranch Prepack

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

REMEDYREPACK INC.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

Rising Pharma Holdings, Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

Preferred Pharmaceuticals, Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

REMEDYREPACK INC.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

Bryant Ranch Prepack

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

Major Pharmaceuticals

Similarity: 77.7%

PIOGLITAZONE

PIOGLITAZONE

Accord Healthcare, Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

American Health Packaging

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

RPK Pharmaceuticals, Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

RPK Pharmaceuticals, Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

AvKARE

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

RPK Pharmaceuticals, Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

A-S Medication Solutions

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

NorthStar RxLLC

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

NuCare Pharmaceuticals,Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

NuCare Pharmaceuticals,Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

Macleods Pharmaceuticals Limited

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

NuCare Pharmaceuticals,Inc.

Similarity: 77.7%

pioglitazone

PIOGLITAZONE

Zydus Pharmaceuticals USA Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

REMEDYREPACK INC.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

Proficient Rx LP

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

Sandoz Inc

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

A-S Medication Solutions

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

REMEDYREPACK INC.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

Coupler LLC

Similarity: 77.7%

Actos

PIOGLITAZONE

Takeda Pharmaceuticals America, Inc.

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

Bryant Ranch Prepack

Similarity: 77.7%

Pioglitazone

PIOGLITAZONE

Teva Pharmaceuticals USA, Inc.

Similarity: 77.7%

PIOGLITAZONEHYDROCHLORIDE

PIOGLITAZONEHYDROCHLORIDE

Proficient Rx LP

Similarity: 77.3%

Actoplus Met

PIOGLITAZONE AND METFORMIN HYDROCHLORIDE

Takeda Pharmaceuticals America, Inc.

Similarity: 69.4%

Pioglitazone hydrochloride and glimepiride

PIOGLITAZONE HYDROCHLORIDE AND GLIMEPIRIDE

Sandoz Inc

Similarity: 67.6%

Saxagliptin and Metformin Hydrochloride

SAXAGLIPTIN AND METFORMIN HYDROCHLORIDE

Dr.Reddys Laboratories Inc

Similarity: 66.2%

Saxagliptin and Metformin

SAXAGLIPTIN AND METFORMIN

Mylan Pharmaceuticals Inc.

Similarity: 63.1%

pioglitazone and glimepiride

PIOGLITAZONE AND GLIMEPIRIDE

Prasco Laboratories

Similarity: 62.6%

Glipizide and Metformin Hydrochloride

GLIPIZIDE AND METFORMIN HYDROCHLORIDE

Teva Pharmaceuticals USA, Inc.

Similarity: 62.1%

JANUMET XR

SITAGLIPTIN AND METFORMIN HYDROCHLORIDE

A-S Medication Solutions

Similarity: 61.3%

STEGLUJAN

ERTUGLIFLOZIN AND SITAGLIPTIN

Merck Sharp & Dohme LLC

Similarity: 60.4%