Pioglitazone Hydrochloride and Metformin Hydrochloride

PIOGLITAZONE HYDROCHLORIDE AND METFORMIN HYDROCHLORIDE

Manufacturer: AvKARE

Score: 148.0

Quick Summary

Pioglitazone Hydrochloride and Metformin Hydrochloride is a combination medication used to improve glycemic control in adults with type 2 diabetes mellitus. It combines pioglitazone, a thiazolidinedione, and metformin, a biguanide, to decrease insulin resistance and improve glucose tolerance. The medication is available in two strengths: 15 mg/500 mg and 15 mg/850 mg. The recommended starting dosage is based on the patient's current regimen, and the maximum recommended total daily dosage is 45 mg of pioglitazone and 2,550 mg of metformin. The medication has several warnings and precautions, including congestive heart failure, lactic acidosis, and liver damage. It is contraindicated in patients with severe renal impairment, acute or chronic metabolic acidosis, and a history of serious hypersensitivity to pioglitazone or metformin.

Key Clinical Findings and Indications

Improves glycemic control in adults with type 2 diabetes mellitus
Decreases insulin resistance and improves glucose tolerance
Available in two strengths: 15 mg/500 mg and 15 mg/850 mg
Recommended starting dosage is based on the patient's current regimen

Important Safety Information

Warning

Congestive heart failure and lactic acidosis

Contraindications

Severe renal impairment
Acute or chronic metabolic acidosis
History of serious hypersensitivity to pioglitazone or metformin

Adverse Reactions

Edema
Weight gain
Hypoglycemia
Liver damage

Dosing Recommendations

General Guidance

Titrate the dosage gradually, as needed, after assessing therapeutic response and tolerability

Type 2 diabetes mellitus

Adult Dose

15 mg/500 mg or 15 mg/850 mg once daily

Pediatric Dose

Not recommended for pediatric patients

Special Population Considerations

Pregnancy

Limited data available
Use with caution

Nursing Mothers

Discuss the potential for unintended pregnancy
Use with caution

Pediatric Use

Not recommended for pediatric patients
Safety and effectiveness have not been established

Geriatric Use

Use with caution
Assess renal function more frequently

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