Saxagliptin and Metformin

Warning

Lactic acidosis, pancreatitis, heart failure, hypoglycemia, and hypersensitivity reactions

Contraindications

• Severe renal impairment (eGFR below 30 mL/min/1.73 m^2)
• Hypersensitivity to metformin hydrochloride
• Acute or chronic metabolic acidosis, including diabetic ketoacidosis
• History of a serious hypersensitivity reaction to saxagliptin and metformin hydrochloride extended-release tablets or saxagliptin

Adverse Reactions

• Diarrhea
• Nausea/vomiting
• Upper respiratory tract infection
• Urinary tract infection
• Headache

General Guidance

Limit saxagliptin dosage to 2.5 mg daily for patients also taking strong cytochrome P450 3A4/5 inhibitors

Pregnancy

• Limited data available
• Use during pregnancy not recommended unless potential benefits justify potential risks

Nursing Mothers

• Caution advised
• Monitor breastfed infant for hypoglycemia

Pediatric Use

• Not established
• Safety and effectiveness not studied in pediatric patients under 18 years of age

Geriatric Use

• Assess renal function more frequently
• Greater sensitivity to adverse effects in elderly patients