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Pioglitazole and metformin hydrochloride

PIOGLITAZOLE AND METFORMIN HYDROCHLORIDE

Manufacturer: Macleods Pharmaceuticals Limited

Score: 148.0

Quick Summary

Pioglitazone and metformin hydrochloride is a combination medication used to improve glycemic control in adults with type 2 diabetes mellitus. It combines pioglitazone, a thiazolidinedione that improves insulin sensitivity, and metformin, a biguanide that decreases hepatic glucose production. The medication is available in various strengths and is typically taken orally with meals to reduce gastrointestinal adverse reactions. Key clinical findings indicate that pioglitazone and metformin hydrochloride is effective in reducing HbA1c levels and improving insulin sensitivity. Important safety information includes warnings about congestive heart failure, lactic acidosis, and liver damage. Contraindications include patients with severe renal impairment, acute or chronic metabolic acidosis, and known hypersensitivity to pioglitazone or metformin. Dosing recommendations vary based on the patient's current regimen and renal function, with a maximum recommended total daily dosage of 45 mg of pioglitazone and 2550 mg of metformin. Special population considerations include use during pregnancy, nursing, pediatric use, and geriatric use, with careful monitoring and dose adjustments as needed.

Key Clinical Findings and Indications

  • Improves glycemic control in adults with type 2 diabetes mellitus
  • Combines pioglitazone and metformin to improve insulin sensitivity and decrease hepatic glucose production
  • Effective in reducing HbA1c levels and improving insulin sensitivity

Important Safety Information

Warning

Congestive heart failure, lactic acidosis, and liver damage

Contraindications

  • Severe renal impairment
  • Acute or chronic metabolic acidosis
  • Known hypersensitivity to pioglitazone or metformin

Adverse Reactions

  • Hypoglycemia
  • Weight gain
  • Edema
  • Fractures
  • Urinary bladder tumors

Dosing Recommendations

General Guidance

Dose adjustments based on renal function and therapeutic response

Type 2 diabetes mellitus

Adult Dose

15 mg of pioglitazone and 850 mg of metformin HCl orally once daily

Pediatric Dose

Not recommended for pediatric patients

Special Population Considerations

Pregnancy

  • Limited data available
  • Use with caution and monitor closely

Nursing Mothers

  • Caution advised
  • Monitor closely for adverse reactions

Pediatric Use

  • Not recommended for pediatric patients
  • Safety and effectiveness not established

Geriatric Use

  • Use with caution
  • Monitor closely for adverse reactions and adjust dose as needed

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