Actoplus Met

PIOGLITAZONE AND METFORMIN HYDROCHLORIDE

Manufacturer: Takeda Pharmaceuticals America, Inc.

Score: 144.0

Quick Summary

Actoplus Met is a combination medication used to treat type 2 diabetes. It contains pioglitazone and metformin, which work together to improve glycemic control. The medication is contraindicated in patients with severe renal impairment, acute or chronic metabolic acidosis, and those with a history of serious hypersensitivity to pioglitazone or metformin. Important safety information includes the risk of congestive heart failure, lactic acidosis, and fractures. The recommended starting dosage is 15 mg of pioglitazone and 850 mg of metformin once daily, with a maximum total daily dosage of 45 mg of pioglitazone and 2,550 mg of metformin. Special population considerations include use during pregnancy, pediatric use, and geriatric use.

Key Clinical Findings and Indications

Actoplus Met is used to treat type 2 diabetes
The medication improves glycemic control
It is contraindicated in patients with severe renal impairment, acute or chronic metabolic acidosis, and those with a history of serious hypersensitivity to pioglitazone or metformin

Important Safety Information

Warning

The medication can cause congestive heart failure, lactic acidosis, and fractures

Contraindications

Severe renal impairment
Acute or chronic metabolic acidosis
History of serious hypersensitivity to pioglitazone or metformin

Adverse Reactions

Congestive heart failure
Lactic acidosis
Fractures
Edema
Hypoglycemia

Dosing Recommendations

General Guidance

The dosage may need to be adjusted based on renal function and other factors

Type 2 diabetes

Adult Dose

15 mg of pioglitazone and 850 mg of metformin once daily

Pediatric Dose

Not recommended for pediatric patients

Special Population Considerations

Pregnancy

The medication should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus

Nursing Mothers

It is not known whether the medication is excreted in human milk

Pediatric Use

The medication is not recommended for pediatric patients

Geriatric Use

The medication should be used with caution in geriatric patients due to the risk of fractures and other adverse reactions

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