Lisinopril

Warning

When pregnancy is detected, discontinue lisinopril as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Contraindications

• History of angioedema or hypersensitivity related to previous treatment with an ACE inhibitor
• Hereditary or idiopathic angioedema
• Co-administration of aliskiren with lisinopril in patients with diabetes

Adverse Reactions

• Hypotension
• Hyperkalemia
• Cough
• Headache
• Dizziness

General Guidance

Dose adjustments may be necessary in patients with renal impairment or those taking diuretics.

Pregnancy

• Lisinopril can cause fetal harm when administered to a pregnant woman
• Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death

Nursing Mothers

• No data are available regarding the presence of lisinopril in human milk
• Lisinopril is present in rat milk

Pediatric Use

• Antihypertensive effects and safety of lisinopril have been established in pediatric patients aged 6 to 16 years
• Safety and effectiveness of lisinopril have not been established in pediatric patients under the age of 6 or in pediatric patients with glomerular filtration rate < 30 mL/min/1.73 m^2

Geriatric Use

• No dosage adjustment with lisinopril is necessary in elderly patients
• Greater sensitivity of some older individuals cannot be ruled out