Lisinopril and Hydrochlorothiazide

LISINOPRIL AND HYDROCHLOROTHIAZIDE

Manufacturer: Aurobindo Pharma Limited

Score: 143.0

Quick Summary

Lisinopril and Hydrochlorothiazide is a combination drug used for the treatment of hypertension. It combines an angiotensin-converting enzyme inhibitor (lisinopril) and a diuretic (hydrochlorothiazide) to help lower blood pressure. The drug is available in three tablet combinations and should not be used as initial therapy. It is essential to monitor patients for potential side effects, such as angioedema, hypotension, and renal impairment. The dosage should be adjusted according to the patient's response, and special considerations should be taken for pregnant women, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

Treatment of hypertension
Combination of lisinopril and hydrochlorothiazide
Available in three tablet combinations
Not for initial therapy

Important Safety Information

Warning

Use in pregnancy can cause injury and even death to the developing fetus

Contraindications

Hypersensitivity to any component of the product
History of angioedema related to previous treatment with an ACE inhibitor
Hereditary or idiopathic angioedema
Anuria or hypersensitivity to other sulfonamide-derived drugs

Adverse Reactions

Angioedema
Hypotension
Renal impairment
Hyperkalemia
Cough
Dizziness
Headache
Fatigue
Orthostatic effects

Dosing Recommendations

General Guidance

Dosage higher than lisinopril 80 mg and hydrochlorothiazide 50 mg should not be used

Hypertension

Adult Dose

10-80 mg of lisinopril and 12.5-50 mg of hydrochlorothiazide

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

Use in pregnancy can cause injury and even death to the developing fetus
Discontinue as soon as possible when pregnancy is detected

Nursing Mothers

It is not known whether lisinopril is secreted in human milk
Thiazides do appear in human milk
A decision should be made whether to discontinue nursing or to discontinue the drug

Pediatric Use

Safety and effectiveness in pediatric patients have not been established

Geriatric Use

Clinical studies did not include sufficient numbers of subjects aged 65 and over
Dose selection should be cautious, usually starting at the low end of the dosing range

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