Captopril

CAPTOPRIL

Manufacturer: American Health Packaging

Score: 143.0

Quick Summary

Captopril is an ACE inhibitor used to treat hypertension, heart failure, and diabetic nephropathy. It works by relaxing blood vessels, making it easier for the heart to pump blood. The recommended initial dose is 25 mg b.i.d. or t.i.d., with a maximum daily dose of 450 mg. Captopril can cause serious side effects, including angioedema, neutropenia, and fetal toxicity, and should be used with caution in patients with renal impairment, pregnancy, or nursing mothers.

Key Clinical Findings and Indications

Hypertension
Heart Failure
Diabetic Nephropathy
Left Ventricular Dysfunction After Myocardial Infarction

Important Safety Information

Warning

Fetal toxicity: use of captopril during pregnancy can cause injury and death to the developing fetus

Contraindications

Hypersensitivity to captopril or other ACE inhibitors
Concomitant use with aliskiren in patients with diabetes
Concomitant use with neprilysin inhibitors

Adverse Reactions

Angioedema
Neutropenia
Hypotension
Proteinuria
Cough

Dosing Recommendations

General Guidance

Reduce dose in patients with renal impairment

Hypertension

Adult Dose

25 mg b.i.d. or t.i.d., titrate to 50 mg b.i.d. or t.i.d.

Pediatric Dose

Not established

Heart Failure

Adult Dose

6.25 or 12.5 mg t.i.d., titrate to 50 mg t.i.d.

Pediatric Dose

Not established

Diabetic Nephropathy

Adult Dose

25 mg t.i.d.

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

Use of captopril during pregnancy can cause fetal toxicity
Discontinue captopril as soon as possible if pregnancy is detected

Nursing Mothers

Captopril is excreted in human milk
Discontinue nursing or discontinue captopril

Pediatric Use

Safety and effectiveness not established
Use with caution in pediatric patients

Geriatric Use

No specific dosage recommendations
Monitor for hypotension and renal function

Similar Drugs

Lisinopril

LISINOPRIL

Preferred Pharmaceuticals, Inc.

Similarity: 68.7%