Accupril

QUINAPRIL HYDROCHLORIDE

Manufacturer: Parke-Davis Div of Pfizer Inc

Score: 147.0

Quick Summary

Accupril is an ACE inhibitor used to treat hypertension and heart failure. It works by relaxing blood vessels, making it easier for the heart to pump blood. The recommended initial dosage is 10 or 20 mg once daily, with adjustments made according to blood pressure response. Accupril can cause side effects such as dizziness, fatigue, and coughing, and can interact with other medications. It is contraindicated in patients with a history of angioedema related to previous treatment with an ACE inhibitor, and should be used with caution in patients with renal impairment, heart failure, and those taking diuretics.

Key Clinical Findings and Indications

Treatment of hypertension
Management of heart failure as adjunctive therapy
Reduction of blood pressure and improvement of symptoms in patients with heart failure

Important Safety Information

Warning

Fetal toxicity: use of Accupril during pregnancy can cause harm to the fetus

Contraindications

Hypersensitivity to Accupril
History of angioedema related to previous treatment with an ACE inhibitor
Concomitant use with a neprilysin inhibitor

Adverse Reactions

Dizziness
Fatigue
Coughing
Nausea and/or vomiting
Abdominal pain
Headache

Dosing Recommendations

General Guidance

Dosage adjustments should be made at intervals of at least 2 weeks, and patients should be monitored for signs of hypotension, orthostasis, and azotemia

Hypertension

Adult Dose

10 or 20 mg once daily

Pediatric Dose

Not established

Heart failure

Adult Dose

5 mg twice daily

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

Use of Accupril during pregnancy can cause harm to the fetus
Discontinue Accupril as soon as possible when pregnancy is detected

Nursing Mothers

Accupril is secreted in human milk
Caution should be exercised when administering Accupril to a nursing woman

Pediatric Use

The safety and effectiveness of Accupril in pediatric patients have not been established
Neonates with a history of in utero exposure to Accupril may require monitoring for hypotension, oliguria, and hyperkalemia

Geriatric Use

Clinical studies of Accupril did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects
Dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range

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LISINOPRIL

Preferred Pharmaceuticals, Inc.

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