glipizide and metformin hcl

GLIPIZIDE AND METFORMIN HCL

Manufacturer: REMEDYREPACK INC.

Score: 141.0

Quick Summary

Glipizide and Metformin HCl is a combination oral antihyperglycemic drug used in the management of type 2 diabetes. It combines glipizide, a sulfonylurea, and metformin hydrochloride, a biguanide, to improve glycemic control. The drug is contraindicated in patients with severe renal impairment, known hypersensitivity to glipizide or metformin, and acute or chronic metabolic acidosis. The initial dose is 2.5 mg/250 mg once daily with meals, with gradual dose escalation to achieve adequate control of blood glucose. The maximum daily dose is 20 mg/2000 mg. Special considerations are needed for use in pregnancy, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

Glipizide and Metformin HCl is used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
The drug is contraindicated in patients with severe renal impairment, known hypersensitivity to glipizide or metformin, and acute or chronic metabolic acidosis.
Glipizide and Metformin HCl has been shown to be effective in reducing HbA1c and FPG in patients with type 2 diabetes.

Important Safety Information

Warning

Lactic acidosis can occur due to metformin accumulation. The risk is increased in patients with renal impairment, hepatic impairment, and heart failure.

Contraindications

Severe renal impairment (eGFR below 30 mL/min/1.73 m^2)
Known hypersensitivity to glipizide or metformin hydrochloride
Acute or chronic metabolic acidosis, including diabetic ketoacidosis

Adverse Reactions

Hypoglycemia
Gastrointestinal reactions such as diarrhea, nausea, and vomiting
Lactic acidosis

Dosing Recommendations

General Guidance

Dose adjustments should be made based on renal function, with a maximum daily dose of 20 mg/2000 mg.

Type 2 diabetes

Adult Dose

2.5 mg/250 mg once daily with meals, with gradual dose escalation to achieve adequate control of blood glucose

Pediatric Dose

Not recommended for pediatric patients

Special Population Considerations

Pregnancy

Glipizide and Metformin HCl is not recommended for use during pregnancy
Insulin therapy should be considered if the drug is discontinued

Nursing Mothers

Glipizide and Metformin HCl should be discontinued in nursing mothers
Insulin therapy should be considered if the drug is discontinued

Pediatric Use

Glipizide and Metformin HCl is not recommended for pediatric patients
Safety and effectiveness have not been established in pediatric patients

Geriatric Use

Dose selection should be cautious in geriatric patients
Assess renal function more frequently in elderly patients

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