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Metoprolol Succinate

METOPROLOL SUCCINATE ER TABLETS

Manufacturer: BluePoint Laboratories

Score: 141.0

Quick Summary

Metoprolol succinate is a beta-adrenergic blocker used to treat hypertension, angina pectoris, and heart failure. It works by reducing the heart rate and blood pressure, and is available in extended-release tablets. The drug has several key clinical findings and indications, including reducing the risk of cardiovascular mortality and heart failure hospitalizations. Important safety information includes warnings about worsening heart failure, bronchospasm, and contraindications such as severe bradycardia and cardiogenic shock. The main dosing recommendations include initial dosing and titration details for different conditions, as well as dose adjustments. Special population considerations include use during pregnancy, nursing mothers, pediatric use, and geriatric use.

Key Clinical Findings and Indications

  • Hypertension
  • Angina Pectoris
  • Heart Failure
  • Reduces risk of cardiovascular mortality and heart failure hospitalizations

Important Safety Information

Warning

Worsening heart failure, bronchospasm

Contraindications

  • Severe bradycardia
  • Second- or third-degree heart block
  • Cardiogenic shock
  • Decompensated heart failure
  • Sick sinus syndrome (unless a permanent pacemaker is in place)
  • Hypersensitivity to any component of the product

Adverse Reactions

  • Tiredness
  • Dizziness
  • Depression
  • Shortness of breath
  • Bradycardia
  • Hypotension
  • Diarrhea
  • Pruritus
  • Rash

Dosing Recommendations

General Guidance

Titrate at weekly or longer intervals as needed and tolerated

Hypertension

Adult Dose

25-100 mg daily

Pediatric Dose

1 mg/kg once daily (maximum initial dose 50 mg once daily)

Angina Pectoris

Adult Dose

100 mg daily

Pediatric Dose

Not applicable

Heart Failure

Adult Dose

12.5-25 mg once daily

Pediatric Dose

Not applicable

Special Population Considerations

Pregnancy

  • Use during pregnancy only if potential benefit justifies potential risk to fetus
  • No adequate and well-controlled studies in pregnant women

Nursing Mothers

  • Caution should be exercised when metoprolol succinate is administered to nursing mothers

Pediatric Use

  • Safety and effectiveness have not been established in patients < 6 years of age

Geriatric Use

  • Use with caution in elderly patients due to potential for decreased hepatic, renal, or cardiac function

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