Bisoprolol Fumarate and Hydrochlorothiazide

BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE

Manufacturer: Mylan Pharmaceuticals Inc.

Score: 141.0

Quick Summary

Bisoprolol Fumarate and Hydrochlorothiazide is a combination medication used to treat hypertension. It combines a beta-blocker (bisoprolol fumarate) and a diuretic (hydrochlorothiazide) to lower blood pressure. The medication is available in various strengths and is typically taken once daily. It is essential to follow the prescribed dosage and titration schedule to minimize adverse effects. The medication has several contraindications, including cardiogenic shock, overt cardiac failure, and hypersensitivity to either component. Adverse reactions may include bradycardia, hypotension, and electrolyte imbalances. Special considerations are necessary for use in pregnancy, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

Hypertension management
Combination of beta-blocker and diuretic
Available in various strengths
Once-daily dosing

Important Safety Information

Warning

May cause bradycardia, hypotension, and electrolyte imbalances

Contraindications

Cardiogenic shock
Overt cardiac failure
Hypersensitivity to either component
Second or third degree AV block
Marked sinus bradycardia
Anuria

Adverse Reactions

Bradycardia
Hypotension
Electrolyte imbalances
Diarrhea
Asthenia
Fatigue

Dosing Recommendations

General Guidance

Dose adjustments may be necessary for patients with renal or hepatic impairment

Hypertension

Adult Dose

Initial dose: 2.5/6.25 mg once daily, titrate every 14 days as needed

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

Use only if potential benefit justifies the risk to the fetus
Thiazides cross the placental barrier and appear in cord blood

Nursing Mothers

Bisoprolol fumarate and HCTZ have not been studied in nursing mothers
Thiazides are excreted in human breast milk

Pediatric Use

Safety and effectiveness have not been established

Geriatric Use

No overall differences in effectiveness or safety were observed between elderly and younger patients
Greater sensitivity of some older individuals cannot be ruled out