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Amlodipine Besylate and Benazepril Hydrochloride

AMLODIPINE BESYLATE AND BENAZEPRIL HYDROCHLORIDE

Manufacturer: A-S Medication Solutions

Score: 144.0

Quick Summary

Amlodipine Besylate and Benazepril Hydrochloride is a combination drug used for the treatment of hypertension in patients not adequately controlled on monotherapy with either agent. It works by inhibiting angiotensin-converting enzyme (ACE) and blocking calcium channels, leading to decreased blood pressure. The drug has several key clinical findings and indications, including the treatment of hypertension, and has important safety information and contraindications, such as the risk of fetal harm when administered to pregnant women. The main dosing recommendations include an initial dose of 2.5/10 mg, with titration up to 10/40 mg once-daily. Special population considerations include use in pregnancy, pediatric use, and geriatric use.

Key Clinical Findings and Indications

  • Treatment of hypertension in patients not adequately controlled on monotherapy with either agent
  • Inhibition of angiotensin-converting enzyme (ACE) and blockade of calcium channels
  • Decreased blood pressure

Important Safety Information

Warning

When pregnancy is detected, discontinue amlodipine and benazepril hydrochloride as soon as possible

Contraindications

  • History of angioedema
  • Hypersensitivity to benazepril or amlodipine
  • Combination with a neprilysin inhibitor

Adverse Reactions

  • Cough
  • Headache
  • Dizziness
  • Edema

Dosing Recommendations

General Guidance

Dose adjustments may be necessary in patients with renal impairment or hepatic impairment

Hypertension

Adult Dose

Initial dose: 2.5/10 mg, titrate up to 10/40 mg once-daily

Pediatric Dose

Special Population Considerations

Pregnancy

  • Discontinue use when pregnancy is detected
  • Risk of fetal harm

Nursing Mothers

  • Unknown effects on nursing infants

Pediatric Use

  • Safety and effectiveness have not been established

Geriatric Use

  • Consider lower initial doses
  • Monitor for hypotension and renal impairment

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