Glyburide

Warning

The administration of oral hypoglycemic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin

Contraindications

• Known hypersensitivity or allergy to the drug
• Diabetic ketoacidosis, with or without coma
• Type 1 diabetes mellitus
• Concomitant administration of bosentan

Adverse Reactions

• Hypoglycemia
• Gastrointestinal reactions
• Dermatologic reactions
• Hematologic reactions
• Metabolic reactions

General Guidance

Dosage increases should be made in increments of no more than 2.5 mg at weekly intervals based upon the patient's blood glucose response

Pregnancy

• Glyburide should be used during pregnancy only if clearly needed
• The drug should be discontinued at least two weeks before the expected delivery date

Nursing Mothers

• A decision should be made whether to discontinue nursing or to discontinue the drug
• If the drug is discontinued, and if diet alone is inadequate for controlling blood glucose, insulin therapy should be considered

Pediatric Use

• Safety and effectiveness in pediatric patients have not been established
• Not recommended for use in pediatric patients

Geriatric Use

• Elderly patients are particularly susceptible to the hypoglycemic action of glucose lowering drugs
• The initial and maintenance dosing should be conservative to avoid hypoglycemic reactions