SOLIFENACIN
Manufacturer: Zydus Pharmaceuticals USA Inc.
Score: 141.0
Solifenacin is a muscarinic receptor antagonist used for the treatment of adults with overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency. The recommended oral dose is 5 mg once daily, which can be increased to 10 mg once daily if well tolerated. However, the dose should not exceed 5 mg once daily in patients with severe renal impairment, moderate hepatic impairment, or when concomitantly used with strong CYP3A4 inhibitors. Solifenacin is contraindicated in patients with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, and hypersensitivity to the drug or its components. The most common adverse reactions include dry mouth, constipation, urinary tract infection, and blurred vision.
Do not exceed the 5 mg dose of solifenacin succinate in patients with severe renal impairment, moderate hepatic impairment, or when concomitantly used with strong CYP3A4 inhibitors
Do not exceed the 5 mg dose of solifenacin succinate in patients with severe renal impairment, moderate hepatic impairment, or when concomitantly used with strong CYP3A4 inhibitors
5 mg once daily, which can be increased to 10 mg once daily if well tolerated
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