Tolterodine Tartrate

TOLTERODINE TARTRATE

Manufacturer: A-S Medication Solutions

Score: 145.0

Quick Summary

Tolterodine Tartrate is a muscarinic receptor antagonist used for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency. The recommended dose is 4 mg once daily, with possible dose reduction to 2 mg daily based on individual response and tolerability. Contraindications include urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma, as well as known hypersensitivity to the drug or its ingredients. Adverse reactions may include dry mouth, headache, constipation, and abdominal pain.

Key Clinical Findings and Indications

Treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and frequency
Muscarinic receptor antagonist

Important Safety Information

Warning

Tolterodine Tartrate is contraindicated in patients with urinary retention, gastric retention, or uncontrolled narrow-angle glaucoma

Contraindications

Urinary retention
Gastric retention
Uncontrolled narrow-angle glaucoma
Known hypersensitivity to the drug or its ingredients

Adverse Reactions

Dry mouth
Headache
Constipation
Abdominal pain

Dosing Recommendations

General Guidance

Dose reduction to 2 mg daily may be necessary in patients with mild to moderate hepatic impairment, severe renal impairment, or those taking potent CYP3A4 inhibitors

Overactive bladder

Adult Dose

4 mg once daily

Pediatric Dose

Not recommended for use in pediatric patients

Special Population Considerations

Pregnancy

No available data on use in pregnant women
Animal studies showed no adverse effects at doses up to 9-12 times the clinical exposure

Nursing Mothers

No information on presence in human milk
Caution advised due to potential for adverse effects in the breastfed infant

Pediatric Use

Not recommended for use in pediatric patients
Efficacy not established in clinical studies

Geriatric Use

No overall differences in safety observed between older and younger patients
Dose adjustment not recommended based on age alone

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