Aripiprazole

Warning

Increased mortality in elderly patients with dementia-related psychosis and suicidal thoughts and behaviors in children, adolescents, and young adults

Contraindications

• Known hypersensitivity to aripiprazole

Adverse Reactions

• Extrapyramidal disorder
• Somnolence
• Tremor
• Akathisia
• Insomnia
• Restlessness
• Fatigue
• Blurred vision
• Nausea
• Vomiting
• Constipation
• Headache
• Dizziness

General Guidance

Dosage adjustments needed for certain populations, such as pediatric and geriatric patients, and for concomitant use with other medications

Pregnancy

• Pregnancy exposure registry available
• Use during pregnancy may increase risk of extrapyramidal and/or withdrawal symptoms in neonates

Nursing Mothers

• Aripiprazole is present in human milk
• Caution advised when administering to nursing mothers

Pediatric Use

• Safety and effectiveness established for schizophrenia, bipolar mania, and irritability associated with autistic disorder
• Not established for major depressive disorder

Geriatric Use

• No dosage adjustment recommended for elderly patients
• Increased risk of mortality and other adverse reactions in elderly patients with dementia-related psychosis