Aripiprazole

ARIPIPRAZOLE ORAL

Manufacturer: Camber Pharmaceuticals, Inc.

Score: 144.0

Quick Summary

Aripiprazole is an atypical antipsychotic used for the treatment of schizophrenia, bipolar disorder, irritability associated with autistic disorder, and Tourette's disorder. It has a boxed warning for increased mortality in elderly patients with dementia-related psychosis and suicidal thoughts and behaviors in children, adolescents, and young adults. The drug is available as an oral solution and has various dosing recommendations for different conditions and patient populations. Special population considerations include use during pregnancy, nursing mothers, pediatric use, and geriatric use.

Key Clinical Findings and Indications

Schizophrenia
Bipolar disorder
Irritability associated with autistic disorder
Tourette's disorder

Important Safety Information

Warning

Increased mortality in elderly patients with dementia-related psychosis and suicidal thoughts and behaviors in children, adolescents, and young adults

Contraindications

Known hypersensitivity to aripiprazole

Adverse Reactions

Extrapyramidal disorder
Somnolence
Fatigue
Nausea
Akathisia
Blurred vision
Salivary hypersecretion
Dizziness

Dosing Recommendations

Nursing Mothers

Aripiprazole is excreted in human breast milk
Caution should be exercised when administering to nursing mothers

Pediatric Use

Safety and efficacy established in pediatric patients 10-17 years old with schizophrenia and bipolar disorder
Safety and efficacy established in pediatric patients 6-17 years old with irritability associated with autistic disorder