Aripiprazole

Warning

Increased mortality in elderly patients with dementia-related psychosis and suicidal thoughts and behaviors in children, adolescents, and young adults

Contraindications

• Known hypersensitivity to aripiprazole

Adverse Reactions

• Extrapyramidal disorder
• Somnolence
• Fatigue
• Nausea
• Akathisia
• Blurred vision
• Salivary hypersecretion
• Dizziness

General Guidance

Dose adjustments may be necessary for patients with hepatic or renal impairment, or those taking concomitant medications that affect CYP2D6 or CYP3A4

Pregnancy

• Pregnancy category C
• Use during pregnancy only if potential benefit justifies potential risk to fetus

Nursing Mothers

• Aripiprazole is excreted in human breast milk
• Caution should be exercised when administering to nursing mothers

Pediatric Use

• Safety and efficacy established in pediatric patients 10-17 years old with schizophrenia and bipolar disorder
• Safety and efficacy established in pediatric patients 6-17 years old with irritability associated with autistic disorder

Geriatric Use

• No dosage adjustment recommended for elderly patients
• Use with caution in elderly patients with dementia-related psychosis