Enalapril maleate and hydrochlorothiazide

ENALAPRIL MALEATE AND HYDROCHLOROTHIAZIDE

Manufacturer: Dr. Reddy's Laboratories Limited

Score: 147.0

Quick Summary

Vaseretic is a combination of enalapril maleate and hydrochlorothiazide used for the treatment of hypertension. The drug works by inhibiting the angiotensin-converting enzyme (ACE) and increasing the excretion of sodium and water, which helps to lower blood pressure. Key clinical findings and indications include the treatment of hypertension, with important safety information and contraindications such as the risk of fetal toxicity, angioedema, and anaphylactoid reactions. Main dosing recommendations include an initial dose of 10-25 mg, with dose adjustments based on clinical response. Special population considerations include the risks associated with use during pregnancy, nursing mothers, pediatric use, and geriatric use.

Key Clinical Findings and Indications

Treatment of hypertension
Inhibition of angiotensin-converting enzyme (ACE)
Increased excretion of sodium and water
Reduction of blood pressure

Important Safety Information

Warning

Risk of fetal toxicity, angioedema, and anaphylactoid reactions

Contraindications

Hypersensitivity to any component of the drug
History of angioedema related to previous treatment with an ACE inhibitor
Hereditary or idiopathic angioedema
Anuria or hypersensitivity to other sulfonamide-derived drugs

Adverse Reactions

Dizziness
Headache
Fatigue
Cough
Orthostatic hypotension
Angioedema
Anaphylactoid reactions

Dosing Recommendations

General Guidance

Based on clinical response, with a maximum daily dose of 20 mg of enalapril and 50 mg of hydrochlorothiazide

Hypertension

Adult Dose

10-25 mg

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

Risk of fetal toxicity
Discontinue use as soon as possible when pregnancy is detected

Nursing Mothers

Enalapril, enalaprilat, and hydrochlorothiazide have been detected in human breast milk
Decisions should be made whether to discontinue nursing or the drug

Pediatric Use

Safety and effectiveness have not been established
Neonates with a history of in utero exposure may require support of blood pressure and renal perfusion

Geriatric Use

Dose selection should be cautious, usually starting at the low end of the dosing range
Evaluation of the hypertensive patient should always include assessment of renal function

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