Telmisartan and Hydrochlorothiazide

TELMISARTAN AND HYDROCHLOROTHIAZIDE

Manufacturer: Alembic Pharmaceuticals Inc.

Score: 144.0

Quick Summary

Telmisartan and Hydrochlorothiazide is a combination drug used to treat hypertension. It combines an angiotensin II receptor blocker (ARB) and a thiazide diuretic to lower blood pressure, reducing the risk of fatal and nonfatal cardiovascular events. The drug is not indicated for initial therapy and should be used with caution in patients with certain conditions, such as renal impairment or hepatic insufficiency. The recommended starting dose is 80 mg/12.5 mg once daily, with titration up to 160 mg/25 mg as needed. Special considerations are necessary for use in pregnancy, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

Hypertension treatment
Reduces risk of fatal and nonfatal cardiovascular events
Combination of angiotensin II receptor blocker (ARB) and thiazide diuretic

Important Safety Information

Warning

When pregnancy is detected, discontinue Telmisartan and Hydrochlorothiazide as soon as possible.

Contraindications

Hypersensitivity to any component of the product
Anuria
Co-administration with aliskiren in patients with diabetes

Adverse Reactions

Upper respiratory tract infection
Dizziness
Sinusitis
Diarrhea
Fatigue
Influenza-like symptoms
Nausea

Dosing Recommendations

General Guidance

Initiate patients with biliary obstructive disorders or hepatic insufficiency at 40 mg/12.5 mg.

Hypertension

Adult Dose

80 mg/12.5 mg once daily, titrate up to 160 mg/25 mg as needed

Pediatric Dose

Special Population Considerations

Pregnancy

Discontinue use as soon as possible when pregnancy is detected
Use of drugs that act on the renin-angiotensin system can cause fetal harm

Nursing Mothers

Advise nursing women not to breastfeed during treatment
Telmisartan is present in the milk of lactating rats

Pediatric Use

Safety and effectiveness have not been established in pediatric patients

Geriatric Use

No overall differences in effectiveness and safety were observed in geriatric patients compared to younger patients
Dose selection should be cautious, usually starting at the low end of the dosing range