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METOPROLOL TARTRATE

METOPROLOL

Manufacturer: Coupler LLC

Score: 145.0

Quick Summary

Metoprolol tartrate is a beta-adrenergic blocker used to treat hypertension, angina pectoris, and myocardial infarction. It works by reducing heart rate, blood pressure, and cardiac output, thereby decreasing the oxygen demand of the heart. The usual initial dosage is 100 mg daily, and it can be increased based on individual patient response. Metoprolol tartrate is contraindicated in patients with severe bradycardia, heart block, cardiogenic shock, and hypersensitivity to the drug. Common adverse reactions include tiredness, dizziness, depression, shortness of breath, bradycardia, and hypotension. Special population considerations include use during pregnancy, nursing mothers, pediatric use, and geriatric use.

Key Clinical Findings and Indications

  • Hypertension
  • Angina Pectoris
  • Myocardial Infarction

Important Safety Information

Warning

Metoprolol tartrate can cause bradycardia, hypotension, and worsening heart failure.

Contraindications

  • Severe bradycardia
  • Second- or third-degree heart block
  • Cardiogenic shock
  • Hypersensitivity to the drug

Adverse Reactions

  • Tiredness
  • Dizziness
  • Depression
  • Shortness of breath
  • Bradycardia
  • Hypotension

Dosing Recommendations

General Guidance

Dose adjustments should be made based on individual patient response and tolerability.

Hypertension

Adult Dose

100 mg daily

Pediatric Dose

Not established

Angina Pectoris

Adult Dose

100 mg daily, given in two divided doses

Pediatric Dose

Not established

Myocardial Infarction

Adult Dose

50 mg every 6 hours, 15 minutes after the last intravenous dose of metoprolol

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

  • Metoprolol tartrate can be used during pregnancy, but it is essential to carefully monitor and manage the patient.

Nursing Mothers

  • Metoprolol tartrate is excreted in breast milk, and caution should be exercised when administering the drug to nursing mothers.

Pediatric Use

  • Safety and effectiveness of metoprolol tartrate have not been established in pediatric patients.

Geriatric Use

  • Clinical studies have not identified significant differences in responses between elderly and younger patients, but dose adjustments may be necessary based on individual patient response and tolerability.

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