Sertraline Hydrochloride

Warning

Suicidal thoughts and behaviors, serotonin syndrome, and increased risk of bleeding

Contraindications

• Concomitant use of MAOIs
• Concomitant use of pimozide
• Known hypersensitivity to sertraline

Adverse Reactions

• Nausea
• Diarrhea
• Tremor
• Dyspepsia
• Decreased appetite
• Hyperhidrosis
• Ejaculation failure
• Decreased libido

General Guidance

Dose adjustments may be necessary for patients with hepatic impairment

Pregnancy

• Use during pregnancy may increase risk of persistent pulmonary hypertension of the newborn
• Use during pregnancy may increase risk of neonatal complications

Nursing Mothers

• Sertraline is excreted in human breast milk
• Caution should be exercised when administering sertraline to nursing women

Pediatric Use

• Safety and efficacy established for OCD in pediatric patients aged 6-17
• Not established for other indications in pediatric patients

Geriatric Use

• No overall differences in safety or effectiveness observed between geriatric and younger patients
• Dose selection should be conservative, starting at the low end of the dosing range