Paroxetine

PAROXETINE HYDROCHLORIDE HEMIHYDRATE

Manufacturer: Proficient Rx LP

Score: 144.0

Quick Summary

Paroxetine is an SSRI used for the treatment of major depressive disorder (MDD), obsessive-compulsive disorder (OCD), panic disorder (PD), social anxiety disorder (SAD), generalized anxiety disorder (GAD), and posttraumatic stress disorder (PTSD). The recommended starting dose varies by condition, and dose adjustments may be necessary. Paroxetine has important safety information, including a boxed warning about suicidal thoughts and behaviors, and contraindications such as use with MAOIs or within 14 days of stopping MAOIs. Special population considerations include use during pregnancy, nursing mothers, pediatric use, and geriatric use.

Key Clinical Findings and Indications

Major depressive disorder (MDD)
Obsessive-compulsive disorder (OCD)
Panic disorder (PD)
Social anxiety disorder (SAD)
Generalized anxiety disorder (GAD)
Posttraumatic stress disorder (PTSD)

Important Safety Information

Warning

Suicidal thoughts and behaviors

Contraindications

Use with MAOIs or within 14 days of stopping MAOIs
Use with pimozide or thioridazine
Known hypersensitivity to paroxetine or any of the inactive ingredients

Adverse Reactions

Abnormal ejaculation
Asthenia
Constipation
Decreased appetite
Diarrhea
Dizziness
Dry mouth
Female genital disorder
Impotence
Infection
Insomnia
Libido decreased
Male genital disorder
Nausea
Nervousness
Somnolence
Sweating
Tremor
Yawn

Dosing Recommendations

Nursing Mothers

Paroxetine is secreted in human milk
A decision should be made whether to discontinue nursing or to discontinue the drug

Pediatric Use

The safety and effectiveness of paroxetine in pediatric patients have not been established
Antidepressants increase the risk of suicidal thoughts and behaviors in pediatric patients

Geriatric Use

In premarketing clinical trials, 17% of patients treated with paroxetine were 65 years of age or older
SSRIs, including paroxetine, have been associated with cases of clinically significant hyponatremia in elderly patients

Similar Drugs

Paroxetine Hydrochloride

PAROXETINE HYDROCHLORIDE

Lannett Company, Inc.

Similarity: 86.0%

Fluoxetine

FLUOXETINE

Cardinal Health 107, LLC

Similarity: 74.2%

Fluoxetine HCl

FLUOXETINE HCL

Almatica Pharma Inc.

Similarity: 72.8%

Sertraline Hydrochloride

SERTRALINE HYDROCHLORIDE

PD-Rx Pharmaceuticals, Inc.

Similarity: 67.2%