Atenolol

ATENOLOL

Manufacturer: PD-Rx Pharmaceuticals, Inc.

Score: 144.0

Quick Summary

Atenolol is a beta blocker used to treat high blood pressure, angina pectoris, and to reduce the risk of heart attack. It works by blocking the action of certain natural chemicals in your body, such as epinephrine, on the heart and blood vessels. This effect lowers the heart rate, blood pressure, and strain on the heart. Atenolol may be used alone or in combination with other medications. It is generally well-tolerated but can cause side effects such as dizziness, fatigue, and nausea. Important safety information includes warnings about exacerbating heart failure, causing bronchospasm in patients with asthma, and potential interactions with other medications. Dosage recommendations vary based on the condition being treated and patient factors like age and kidney function. Special population considerations include use during pregnancy, nursing, pediatric, and geriatric populations, where dose adjustments and careful monitoring may be necessary.

Key Clinical Findings and Indications

Treatment of hypertension to lower blood pressure
Long-term management of patients with angina pectoris
Reduction of cardiovascular mortality in patients with definite or suspected acute myocardial infarction

Important Safety Information

Warning

Patients with coronary artery disease should be advised against abrupt discontinuation of therapy, as severe exacerbation of angina and the occurrence of myocardial infarction and ventricular arrhythmias have been reported.

Contraindications

Sinus bradycardia
Heart block greater than first degree
Cardiogenic shock
Overt cardiac failure
Hypersensitivity to atenolol or any of the drug product's components

Adverse Reactions

Bradycardia
Cold extremities
Postural hypotension
Dizziness
Vertigo
Light-headedness
Tiredness
Fatigue
Lethargy
Drowsiness
Depression
Dreaming
Diarrhea
Nausea
Wheeziness
Dyspnea

Dosing Recommendations

General Guidance

Dose adjustments may be necessary in patients with renal impairment, elderly patients, or those with other underlying health conditions.

Hypertension

Adult Dose

50 mg once daily, with a maximum dose of 100 mg once daily

Pediatric Dose

Not established

Angina pectoris

Adult Dose

50 mg once daily, with a maximum dose of 200 mg once daily

Pediatric Dose

Not established

Acute myocardial infarction

Adult Dose

5 mg intravenous injection, followed by 50 mg oral dose 10 minutes later, then 100 mg once daily or 50 mg twice daily for 6 to 9 days

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

Atenolol can cause fetal harm when administered to a pregnant woman
Use with caution and only when benefits outweigh risks

Nursing Mothers

Atenolol is excreted in human breast milk
Caution should be exercised when atenolol is administered to a nursing woman

Pediatric Use

Safety and effectiveness in pediatric patients have not been established

Geriatric Use

Dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range
Assessment of renal function is recommended