Ibuprofen

IBUPROFEN

Manufacturer: A-S Medication Solutions

Score: 144.0

Quick Summary

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain, reduce inflammation, and lower fever. It is commonly used to treat rheumatoid arthritis, osteoarthritis, and mild to moderate pain. However, it can cause serious side effects, including increased risk of heart attack, stroke, and gastrointestinal bleeding. The recommended dosage is 1200-3200 mg daily, and it should be used with caution in patients with certain medical conditions, such as asthma, heart disease, and kidney disease.

Key Clinical Findings and Indications

Relieves pain, reduces inflammation, and lowers fever
Treats rheumatoid arthritis, osteoarthritis, and mild to moderate pain
Comparable to aspirin in controlling pain and inflammation, but with fewer gastrointestinal side effects

Important Safety Information

Warning

Increased risk of heart attack, stroke, and gastrointestinal bleeding

Contraindications

Hypersensitivity to ibuprofen
Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Coronary artery bypass graft (CABG) surgery

Adverse Reactions

Gastrointestinal complaints, such as nausea, vomiting, and diarrhea
Cardiovascular events, such as heart attack and stroke
Renal toxicity and liver damage

Dosing Recommendations

General Guidance

Use the lowest effective dose for the shortest duration consistent with individual patient treatment goals

Rheumatoid arthritis and osteoarthritis

Adult Dose

1200-3200 mg daily

Pediatric Dose

Not established

Mild to moderate pain

Adult Dose

400 mg every 4-6 hours as necessary

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

Use with caution between 20-30 weeks of gestation
Avoid use at 30 weeks of gestation and later due to risk of premature closure of the fetal ductus arteriosus

Nursing Mothers

It is not known whether ibuprofen is excreted in human milk
Caution should be exercised when administering ibuprofen to nursing mothers

Pediatric Use

Safety and effectiveness have not been established in pediatric patients

Geriatric Use

Caution should be exercised when treating the elderly (65 years and older)

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