Etodolac

ETODOLAC

Manufacturer: Golden State Medical Supply, Inc.

Score: 144.0

Quick Summary

Etodolac is a nonsteroidal anti-inflammatory drug (NSAID) used for the management of signs and symptoms of osteoarthritis, rheumatoid arthritis, and for the management of acute pain. It has anti-inflammatory, analgesic, and antipyretic activities. However, it is associated with serious cardiovascular and gastrointestinal risks, and its use should be carefully considered in patients with certain medical conditions. The recommended dose is 200-400 mg every 6-8 hours for acute pain, and 300-500 mg twice a day for osteoarthritis and rheumatoid arthritis. Special considerations are needed for use in pregnancy, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

Osteoarthritis
Rheumatoid arthritis
Acute pain

Important Safety Information

Warning

Cardiovascular thrombotic events, gastrointestinal bleeding, and renal impairment

Contraindications

Known hypersensitivity to etodolac
Aspirin triad
Coronary artery bypass graft surgery

Adverse Reactions

Gastrointestinal experiences
Abnormal renal function
Anemia
Dizziness
Edema

Dosing Recommendations

General Guidance

Dose adjustment is generally not required in patients with mild to moderate renal impairment, but caution is advised in patients with severe renal impairment.

Acute pain

Adult Dose

200-400 mg every 6-8 hours

Pediatric Dose

Not established

Osteoarthritis and rheumatoid arthritis

Adult Dose

300-500 mg twice a day

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

Use with caution between 20-30 weeks gestation
Avoid use at 30 weeks gestation and later

Nursing Mothers

Trace amounts of etodolac may be excreted in human milk
Caution advised

Pediatric Use

Safety and effectiveness not established in pediatric patients below 18 years

Geriatric Use

Caution advised due to increased risk of gastrointestinal and renal adverse effects
Monitor renal function

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