GLYBURIDE
Manufacturer: A-S Medication Solutions
Score: 141.0
Glyburide is an oral blood-glucose-lowering drug of the sulfonylurea class, used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. The usual starting dose is 2.5 to 5 mg daily, and the maximum daily dose is 20 mg. Glyburide is contraindicated in patients with known hypersensitivity, diabetic ketoacidosis, and type 1 diabetes mellitus. Important safety information includes the risk of hypoglycemia, cardiovascular mortality, and liver enzyme elevations. Special population considerations include use during pregnancy, nursing mothers, pediatric use, and geriatric use.
The administration of oral hypoglycemic drugs has been reported to be associated with increased cardiovascular mortality as compared to treatment with diet alone or diet plus insulin
Dosage increases should be made in increments of no more than 2.5 mg at weekly intervals based upon the patient's blood glucose response
2.5 to 5 mg daily, administered with breakfast or the first main meal
Not recommended for use in pediatric patients
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