SPIRONOLACTONE
Manufacturer: RPK Pharmaceuticals, Inc.
Score: 141.0
Spironolactone is an aldosterone antagonist used for the treatment of heart failure, hypertension, edema associated with cirrhosis or nephrotic syndrome, and primary hyperaldosteronism. It works by blocking the effects of aldosterone, leading to increased excretion of sodium and water, and retention of potassium. The drug has several important safety considerations, including the risk of hyperkalemia, hypotension, and worsening renal function. It is contraindicated in patients with hyperkalemia, Addison's disease, and concomitant use of eplerenone. Dosing recommendations vary depending on the condition being treated, and special population considerations include use during pregnancy, pediatric use, and geriatric use.
Risk of hyperkalemia, hypotension, and worsening renal function
Dose adjustments may be necessary in patients with renal impairment or hepatic impairment
25 mg once daily, titrate to 50 mg once daily as needed
Not established
25-100 mg daily, in single or divided doses
Not established
100 mg daily, in single or divided doses
Not established
100-400 mg daily, in preparation for surgery or as long-term maintenance therapy
Not established