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CaroSpir

CAROSPIR

Manufacturer: CMP Pharma, Inc.

Score: 141.0

Quick Summary

CaroSpir (Spironolactone) is an aldosterone antagonist used in the management of heart failure, hypertension, and edema associated with hepatic cirrhosis. It works by blocking the effects of aldosterone, leading to increased excretion of sodium and water, and retention of potassium. The drug is available as an oral suspension and should be taken consistently with respect to food. Important safety information includes the risk of hyperkalemia, hypotension, and worsening renal function. Contraindications include hyperkalemia, Addison's disease, and concomitant use of eplerenone. Special population considerations include use in pregnancy, pediatric use, geriatric use, and patients with renal or hepatic impairment.

Key Clinical Findings and Indications

  • Treatment of NYHA Class III-IV heart failure and reduced ejection fraction
  • Treatment of hypertension
  • Management of edema associated with hepatic cirrhosis

Important Safety Information

Warning

Risk of hyperkalemia, hypotension, and worsening renal function

Contraindications

  • Hyperkalemia
  • Addison's disease
  • Concomitant use of eplerenone

Adverse Reactions

  • Hyperkalemia
  • Hypotension
  • Gynecomastia
  • Impaired neurological function/coma in patients with hepatic impairment, cirrhosis, and ascites

Dosing Recommendations

General Guidance

Dose adjustments may be necessary in patients with renal impairment or hepatic cirrhosis

Heart Failure

Adult Dose

20 mg once daily, titrate as needed

Pediatric Dose

Hypertension

Adult Dose

20-75 mg daily, in single or divided doses

Pediatric Dose

Edema associated with Hepatic Cirrhosis

Adult Dose

75 mg daily, in single or divided doses

Pediatric Dose

Special Population Considerations

Pregnancy

  • Use with caution, as spironolactone may affect sex differentiation of the male during embryogenesis

Nursing Mothers

Pediatric Use

  • Safety and effectiveness not established in pediatric patients

Geriatric Use

  • Monitor renal function, as elderly patients are more likely to have decreased renal function

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