Moxifloxacin

MOXIFLOXACIN

Manufacturer: A-S Medication Solutions

Score: 148.0

Quick Summary

Moxifloxacin is a fluoroquinolone antibacterial agent used to treat various infections, including community-acquired pneumonia, skin and skin structure infections, intra-abdominal infections, plague, acute bacterial sinusitis, and acute bacterial exacerbation of chronic bronchitis. It is essential to consider the potential risks, including tendonitis, tendon rupture, peripheral neuropathy, and central nervous system effects, particularly in elderly patients and those with certain medical conditions. The recommended dose is 400 mg once daily, with adjustments for patients with renal or hepatic impairment. Special population considerations include use during pregnancy, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

Community-acquired pneumonia
Skin and skin structure infections
Intra-abdominal infections
Plague
Acute bacterial sinusitis
Acute bacterial exacerbation of chronic bronchitis

Important Safety Information

Warning

Fluoroquinolones, including moxifloxacin, have been associated with disabling and potentially irreversible serious adverse reactions, including tendinitis, tendon rupture, peripheral neuropathy, and central nervous system effects.

Contraindications

Hypersensitivity to moxifloxacin or any member of the quinolone class of antibacterials

Adverse Reactions

Nausea
Diarrhea
Headache
Dizziness
Tendinitis
Tendon rupture
Peripheral neuropathy
Central nervous system effects

Dosing Recommendations

General Guidance

No dosage adjustment is necessary for patients with renal or hepatic impairment.

Community-acquired pneumonia

Adult Dose

400 mg once daily for 7 to 14 days

Pediatric Dose

Skin and skin structure infections

Adult Dose

400 mg once daily for 7 to 21 days

Pediatric Dose

Special Population Considerations

Pregnancy

Moxifloxacin may cause fetal harm; use only if potential benefits justify potential risks

Nursing Mothers

It is not known if moxifloxacin is present in human milk; use caution

Pediatric Use

Effectiveness in pediatric patients has not been established; use caution

Geriatric Use

Geriatric patients are at increased risk for developing severe tendon disorders; use caution

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