Ciprofloxacin

Warning

Fluoroquinolones, including ciprofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions, including tendinitis and tendon rupture, peripheral neuropathy, and central nervous system effects.

Contraindications

• Hypersensitivity to ciprofloxacin or other quinolones
• Concomitant administration with tizanidine

Adverse Reactions

• Tendinitis and tendon rupture
• Peripheral neuropathy
• Central nervous system effects
• Exacerbation of myasthenia gravis
• Hypersensitivity reactions
• Hepatotoxicity
• Risk of aortic aneurysm and dissection

General Guidance

Dosage adjustments may be required in patients with renal impairment.

Pregnancy

• Ciprofloxacin should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
• Prolonged experience with ciprofloxacin in pregnant women has not identified any drug-associated risk of major birth defects.

Nursing Mothers

• Ciprofloxacin is excreted in human milk.
• Caution should be exercised when ciprofloxacin is administered to a nursing woman.

Pediatric Use

• Ciprofloxacin is indicated for the treatment of complicated urinary tract infections and pyelonephritis in pediatric patients 1 to 17 years of age.
• The safety and effectiveness of ciprofloxacin in pediatric patients have not been established for other indications.

Geriatric Use

• Geriatric patients are at increased risk for developing severe tendon disorders, including tendon rupture, when being treated with a fluoroquinolone such as ciprofloxacin.
• Caution should be used when prescribing ciprofloxacin to elderly patients, especially those on corticosteroids.