DOPamine Hydrochloride

DOPAMINE HYDROCHLORIDE

Manufacturer: Hospira, Inc.

Score: 141.0

Quick Summary

Dopamine Hydrochloride is a sympathomimetic amine vasopressor used to improve hemodynamic status in patients with distributive shock or shock due to reduced cardiac output. It is administered as a continuous intravenous infusion, with a recommended starting dose of 2-5 mcg/kg/minute, titrated to effect. The drug has several important safety considerations, including contraindications in patients with pheochromocytoma, and potential interactions with other medications. Special population considerations include use in pregnancy, pediatric use, and geriatric use.

Key Clinical Findings and Indications

Improves hemodynamic status in patients with distributive shock or shock due to reduced cardiac output
Increases cardiac output and blood pressure
Vasodilatory effects at low doses, vasoconstrictive effects at high doses

Important Safety Information

Warning

Contraindicated in patients with pheochromocytoma

Contraindications

Pheochromocytoma

Adverse Reactions

Tissue ischemia
Cardiac arrhythmias
Hypotension
Severe hypersensitivity reactions

Dosing Recommendations

General Guidance

Titrate dose based on hemodynamic response and tolerability, up to a maximum of 50 mcg/kg/minute

Distributive shock or shock due to reduced cardiac output

Adult Dose

2-5 mcg/kg/minute, titrated to effect

Pediatric Dose

2-5 mcg/kg/minute, titrated to effect

Special Population Considerations

Pregnancy

No human data available, animal studies suggest potential adverse effects on fetal development

Nursing Mothers

Pediatric Use

Dopamine HCl infusions have been used in pediatric patients from birth through adolescence, with similar dosing to adults

Geriatric Use

Clinical studies did not include sufficient numbers of subjects aged 65 and over, dose selection should start at the low end of the dosing range

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