EPINEPHRINE
Manufacturer: ARS Pharmaceuticals Operations, Inc.
Score: 141.0
Epinephrine is a sympathomimetic catecholamine used to increase mean arterial blood pressure in adult patients with hypotension associated with septic shock, for emergency treatment of allergic reactions (Type 1), including anaphylaxis, and for induction and maintenance of mydriasis during intraocular surgery. It has a rapid onset and short duration of action, and is extensively metabolized with a small amount excreted unchanged. The most common adverse reactions include headache, anxiety, apprehensiveness, restlessness, tremor, weakness, dizziness, sweating, palpitations, pallor, peripheral coldness, nausea/vomiting, and respiratory difficulties. The recommended dosing varies by condition, with intravenous infusion rates of 0.05 mcg/kg/min to 2 mcg/kg/min for hypotension associated with septic shock, and 0.3 to 0.5 mg (0.3 to 0.5 mL) intramuscularly or subcutaneously for anaphylaxis. Special population considerations include use during pregnancy, nursing mothers, pediatric use, and geriatric use, with caution advised due to potential risks and limited clinical data.
Epinephrine should be used with caution in patients with heart disease, hypertension, or hyperthyroidism, and in patients receiving drugs that sensitize the heart to arrhythmias.
Dose adjustments should be made based on clinical response and tolerance.
Intravenous infusion rate of 0.05 mcg/kg/min to 2 mcg/kg/min
Not established
0.3 to 0.5 mg (0.3 to 0.5 mL) intramuscularly or subcutaneously
0.01 mg/kg (0.01 mL/kg) intramuscularly or subcutaneously