Paroxetine

Warning

Suicidal thoughts and behaviors

Contraindications

• Use with MAOIs or within 14 days of stopping MAOIs
• Use with pimozide or thioridazine
• Known hypersensitivity to paroxetine or any of the inactive ingredients

Adverse Reactions

• Abnormal ejaculation
• Asthenia
• Constipation
• Decreased appetite
• Diarrhea
• Dizziness
• Dry mouth
• Female genital disorder
• Impotence
• Infection
• Insomnia
• Libido decreased
• Male genital disorder
• Nausea
• Nervousness
• Somnolence
• Sweating
• Tremor
• Yawn

General Guidance

Dose adjustments may be necessary based on patient response and tolerability

Pregnancy

• Use during pregnancy may increase the risk of congenital malformations
• Use during the third trimester may increase the risk of persistent pulmonary hypertension of the newborn

Nursing Mothers

• Paroxetine is secreted in human milk
• A decision should be made whether to discontinue nursing or to discontinue the drug

Pediatric Use

• The safety and effectiveness of paroxetine in pediatric patients have not been established
• Antidepressants increase the risk of suicidal thoughts and behaviors in pediatric patients

Geriatric Use

• In premarketing clinical trials, 17% of patients treated with paroxetine were 65 years of age or older
• SSRIs, including paroxetine, have been associated with cases of clinically significant hyponatremia in elderly patients