Trifena

DICLOFENAC, LIDOCAINE, MENTHOL

Manufacturer: Trifluent Pharma LLC

Score: 143.89

Quick Summary

Trifena patch is a topical pain relief medication containing diclofenac sodium, lidocaine, and menthol, used for temporary relief of pain associated with arthritis, backache, cramps, discomfort, neck ache, soreness, sprains, and strains. It should be applied to intact skin and used with caution in patients with certain medical conditions, such as asthma, heart failure, or liver disease. The medication has potential interactions with other drugs, including anticoagulants, aspirin, and diuretics, and may cause adverse reactions, such as skin irritation, gastrointestinal bleeding, or cardiovascular events.

Key Clinical Findings and Indications

Temporary relief of pain associated with arthritis, backache, cramps, discomfort, neck ache, soreness, sprains, and strains
Topical application to intact skin

Important Safety Information

Warning

Risk of serious cardiovascular and gastrointestinal events

Contraindications

Known hypersensitivity to diclofenac
Asthma, urticaria, or allergic-type reactions after taking aspirin or other NSAIDs
Severe heart failure
Non-intact or damaged skin

Adverse Reactions

Skin irritation
Gastrointestinal bleeding
Cardiovascular events
Hepatotoxicity

Dosing Recommendations

General Guidance

No specific dose adjustments recommended, but caution advised in patients with certain medical conditions

Pain relief

Adult Dose

Apply to intact skin, up to 2 times daily, for no longer than 12 hours per application

Pediatric Dose

Special Population Considerations

Pregnancy

Category C prior to 30 weeks gestation
Category D starting 30 weeks gestation
Avoid use in pregnant women starting at 30 weeks of gestation

Nursing Mothers

Diclofenac may be present in human milk
Caution advised when using in nursing mothers

Pediatric Use

Safety and effectiveness not established in pediatric patients

Geriatric Use

Elderly patients at greater risk for NSAID-associated serious cardiovascular, gastrointestinal, and/or renal adverse reactions
Start dosing at the low end of the dosing range and monitor for adverse effects

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