METHYLNALTREXONE BROMIDE
Manufacturer: Salix Pharmaceuticals, Inc.
Score: 141.0
Relistor (methylnaltrexone bromide) is a mu-opioid receptor antagonist used for the treatment of opioid-induced constipation (OIC) in adults with chronic non-cancer pain and advanced illness. It works by decreasing the constipating effects of opioids without impacting opioid-mediated analgesic effects on the central nervous system. The recommended dosage is 450 mg once daily in the morning for OIC in adult patients with chronic non-cancer pain, and 12 mg subcutaneously once daily for OIC in adult patients with advanced illness. Relistor is contraindicated in patients with known or suspected gastrointestinal obstruction and patients at increased risk of recurrent obstruction. Common adverse reactions include abdominal pain, diarrhea, and nausea.
Gastrointestinal perforation, severe or persistent diarrhea, and opioid withdrawal
Dosage adjustments may be necessary in patients with renal or hepatic impairment
450 mg once daily in the morning
Not established
12 mg subcutaneously once daily
Not established
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