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Tigecycline

TIGECYCLINE

Manufacturer: Fresenius Kabi USA, LLC

Score: 148.0

Quick Summary

Tigecycline is a tetracycline-class antibacterial used to treat complicated skin and skin structure infections, complicated intra-abdominal infections, and community-acquired bacterial pneumonia in patients 18 years and older. It has a boxed warning regarding increased mortality risk and should be reserved for use when alternative treatments are not suitable. The recommended dosage is an initial 100mg dose followed by 50mg every 12 hours, with adjustments for severe hepatic impairment. Special considerations are needed for use in pregnancy, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

  • Complicated skin and skin structure infections
  • Complicated intra-abdominal infections
  • Community-acquired bacterial pneumonia

Important Safety Information

Warning

Increased mortality risk

Contraindications

  • Known hypersensitivity to tigecycline

Adverse Reactions

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Headache

Dosing Recommendations

General Guidance

Severe hepatic impairment (Child Pugh C): initial dose 100mg, followed by 25mg every 12 hours

Complicated skin and skin structure infections or complicated intra-abdominal infections

Adult Dose

100mg initial dose, followed by 50mg every 12 hours

Pediatric Dose

Not recommended for patients under 18 years

Community-acquired bacterial pneumonia

Adult Dose

100mg initial dose, followed by 50mg every 12 hours

Pediatric Dose

Not recommended for patients under 18 years

Special Population Considerations

Pregnancy

  • Tigecycline should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus

Nursing Mothers

  • Caution should be exercised when tigecycline is administered to a nursing woman

Pediatric Use

  • Use in patients under 18 years of age is not recommended

Geriatric Use

  • No overall differences in safety or effectiveness were observed between geriatric and younger subjects

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