Oxycodone Hydrochloride

OXYCODONE

Manufacturer: Bryant Ranch Prepack

Score: 148.0

Quick Summary

Oxycodone Hydrochloride is an opioid agonist indicated for the management of pain severe enough to require an opioid analgesic and for which alternative treatments are inadequate. It is available in various strengths, including 5mg, 10mg, 15mg, 20mg, and 30mg tablets. The drug has a boxed warning for serious and life-threatening risks, including addiction, abuse, and misuse, life-threatening respiratory depression, and neonatal opioid withdrawal syndrome. Key clinical findings and indications include the treatment of severe pain, with important safety information and contraindications such as significant respiratory depression, acute or severe bronchial asthma, and known or suspected gastrointestinal obstruction. Main dosing recommendations include an initial dose of 5-15mg every 4-6 hours as needed for pain, with dose adjustments based on individual patient response. Special population considerations include use during pregnancy, nursing mothers, pediatric use, and geriatric use, with caution advised in these populations due to potential risks and side effects.

Key Clinical Findings and Indications

Treatment of severe pain
Management of pain severe enough to require an opioid analgesic
Alternative treatments are inadequate

Important Safety Information

Warning

Serious and life-threatening risks, including addiction, abuse, and misuse, life-threatening respiratory depression, and neonatal opioid withdrawal syndrome

Contraindications

Significant respiratory depression
Acute or severe bronchial asthma
Known or suspected gastrointestinal obstruction
Hypersensitivity to oxycodone

Adverse Reactions

Nausea
Constipation
Vomiting
Headache
Pruritus
Insomnia
Dizziness
Asthenia
Somnolence

Dosing Recommendations

General Guidance

Dose adjustments based on individual patient response

Severe pain

Adult Dose

5-15mg every 4-6 hours as needed

Pediatric Dose

Not recommended for pediatric use

Special Population Considerations

Pregnancy

Use of opioid analgesics for an extended period of time during pregnancy may cause neonatal opioid withdrawal syndrome
Oxycodone HCl is not recommended for use in pregnant women during or immediately prior to labor

Nursing Mothers

Oxycodone is known to be excreted in breast milk
Caution advised when using Oxycodone HCl in nursing mothers

Pediatric Use

The safety and efficacy of oxycodone HCl in pediatric patients have not been evaluated
Not recommended for pediatric use

Geriatric Use

Elderly patients may have increased sensitivity to oxycodone
Caution advised when selecting a dosage for an elderly patient
Titrate the dosage of oxycodone HCl slowly in geriatric patients