Home About
Back to Search

Amlodipine and Olmesartan Medoxomil

AMLODIPINE AND OLMESARTAN MEDOXOMIL

Manufacturer: medsource pharmaceuticals

Score: 148.0

Quick Summary

Amlodipine and Olmesartan Medoxomil is a combination medication used to treat high blood pressure. It combines a calcium channel blocker (amlodipine) and an angiotensin II receptor blocker (olmesartan medoxomil) to help lower blood pressure and reduce the risk of cardiovascular events. The medication is available in various strengths and is typically taken once daily. It is essential to follow dosing recommendations and monitor blood pressure regularly. Special considerations are necessary for pregnant women, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

  • Treatment of hypertension
  • Reduction of risk of fatal and nonfatal cardiovascular events
  • Combination of a calcium channel blocker and an angiotensin II receptor blocker

Important Safety Information

Warning

When pregnancy is detected, discontinue amlodipine and olmesartan medoxomil tablets as soon as possible. Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus.

Contraindications

  • Do not co-administer aliskiren with amlodipine and olmesartan medoxomil tablets in patients with diabetes

Adverse Reactions

  • Edema
  • Dizziness
  • Hypotension
  • Hyperkalemia

Dosing Recommendations

General Guidance

The lowest dose of amlodipine and olmesartan medoxomil tablets is 5/20 mg; therefore, initial therapy with amlodipine and olmesartan medoxomil tablets is not recommended in patients ≥75 years old.

Hypertension

Adult Dose

5/20 mg once daily, titrate as needed in two week intervals up to a maximum of 10/40 mg once daily

Pediatric Dose

Special Population Considerations

Pregnancy

  • Discontinue amlodipine and olmesartan medoxomil tablets as soon as possible when pregnancy is detected

Nursing Mothers

  • It is not known whether the amlodipine or olmesartan medoxomil components of amlodipine and olmesartan medoxomil tablets are excreted in human milk

Pediatric Use

  • The safety and effectiveness of amlodipine and olmesartan medoxomil tablets in pediatric patients have not been established

Geriatric Use

  • Elderly patients have decreased clearance of amlodipine, starting amlodipine or adding amlodipine at 2.5 mg in patients ≥75 years old is recommended
Back to Search