Piroxicam

PIROXICAM

Manufacturer: Proficient Rx LP

Score: 141.0

Quick Summary

Piroxicam is a nonsteroidal anti-inflammatory drug (NSAID) used for the relief of symptoms of osteoarthritis and rheumatoid arthritis. It works by inhibiting the production of prostaglandins, which are mediators of inflammation. Piroxicam has a long half-life, allowing for once-daily dosing, but its use is associated with an increased risk of serious cardiovascular and gastrointestinal events. The recommended dose is 20 mg once daily, and dose adjustments may be necessary in certain populations, such as the elderly or those with renal impairment. Piroxicam is contraindicated in patients with known hypersensitivity to the drug, a history of asthma or allergic reactions to NSAIDs, or in the setting of coronary artery bypass graft surgery.

Key Clinical Findings and Indications

Relief of symptoms of osteoarthritis
Relief of symptoms of rheumatoid arthritis
Inhibition of prostaglandin production

Important Safety Information

Warning

Increased risk of serious cardiovascular and gastrointestinal events

Contraindications

Known hypersensitivity to piroxicam or any components of the drug product
History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs
In the setting of coronary artery bypass graft surgery

Adverse Reactions

Nausea
Constipation
Flatulence
Abdominal pain
Diarrhea
Headache
Dizziness
Edema
Rash

Dosing Recommendations

General Guidance

Dose adjustments may be necessary in certain populations, such as the elderly or those with renal impairment

Osteoarthritis

Adult Dose

20 mg once daily

Pediatric Dose

Not established

Rheumatoid arthritis

Adult Dose

20 mg once daily

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

Use during pregnancy only if the potential benefit justifies the potential risk to the fetus
Avoid use in pregnant women starting at 30 weeks of gestation

Nursing Mothers

Piroxicam is excreted in human milk
Use with caution in nursing mothers

Pediatric Use

Piroxicam has not been investigated in pediatric patients
The safety and effectiveness of piroxicam have not been established

Geriatric Use

Elderly patients are at greater risk for NSAID-associated serious cardiovascular, gastrointestinal, and/or renal adverse reactions
Start dosing at the low end of the dosing range and monitor patients for adverse effects

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