NETUPITANT AND PALONOSETRON
Manufacturer: Helsinn Therapeutics (U.S.), Inc.
Score: 141.0
AKYNZEO is a combination drug used for the prevention of acute and delayed nausea and vomiting associated with initial and repeat courses of cancer chemotherapy. It contains netupitant, a substance P/neurokinin 1 (NK-1) receptor antagonist, and palonosetron, a serotonin-3 (5-HT3) receptor antagonist. The drug is available in capsule and injection forms, with the injection form requiring dilution prior to administration. AKYNZEO has been shown to be effective in preventing nausea and vomiting in patients receiving highly emetogenic chemotherapy, including cisplatin-based chemotherapy. However, it is not recommended for use in patients with severe renal impairment or end-stage renal disease. The most common adverse reactions associated with AKYNZEO include headache, asthenia, dyspepsia, fatigue, constipation, and erythema.
Hypersensitivity reactions, including anaphylaxis, have been reported in patients receiving AKYNZEO
No dose adjustment is necessary for patients with mild or moderate renal impairment
One AKYNZEO capsule administered 1 hour prior to the start of chemotherapy
Not established
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