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Lenvima

LENVATINIB

Manufacturer: Eisai Inc.

Score: 141.0

Quick Summary

Lenvima (Lenvatinib) is a kinase inhibitor used for the treatment of various types of cancer, including differentiated thyroid cancer, renal cell carcinoma, hepatocellular carcinoma, and endometrial carcinoma. It works by inhibiting certain enzymes involved in cancer cell growth and proliferation. The recommended dosage varies depending on the specific cancer type and patient population, and dose adjustments may be necessary based on individual patient tolerance and response. Lenvima can cause serious side effects, including hypertension, cardiac dysfunction, and hepatic impairment, and is contraindicated in patients with certain medical conditions. Special considerations are needed for use in pregnant women, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

  • Treatment of differentiated thyroid cancer
  • Treatment of renal cell carcinoma
  • Treatment of hepatocellular carcinoma
  • Treatment of endometrial carcinoma

Important Safety Information

Warning

Lenvima can cause serious side effects, including hypertension, cardiac dysfunction, and hepatic impairment

Contraindications

  • None

Adverse Reactions

  • Hypertension
  • Fatigue
  • Diarrhea
  • Arthralgia/myalgia
  • Decreased appetite
  • Decreased weight
  • Nausea
  • Stomatitis
  • Headache
  • Vomiting
  • Proteinuria
  • Palmar-plantar erythrodysesthesia syndrome
  • Abdominal pain
  • Dysphonia

Dosing Recommendations

General Guidance

Dose adjustments may be necessary based on individual patient tolerance and response

Differentiated thyroid cancer

Adult Dose

24 mg orally once daily

Pediatric Dose

Not established

Renal cell carcinoma

Adult Dose

20 mg orally once daily in combination with pembrolizumab 200 mg intravenously every 3 weeks

Pediatric Dose

Not established

Hepatocellular carcinoma

Adult Dose

12 mg orally once daily for patients ≥60 kg or 8 mg orally once daily for patients <60 kg

Pediatric Dose

Not established

Endometrial carcinoma

Adult Dose

20 mg orally once daily in combination with pembrolizumab 200 mg intravenously every 3 weeks

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

  • Lenvima can cause fetal harm when administered to a pregnant woman

Nursing Mothers

  • It is not known whether lenvatinib is excreted in human milk

Pediatric Use

  • The safety and effectiveness of Lenvima in pediatric patients have not been established

Geriatric Use

  • No overall differences in safety or effectiveness were observed between elderly patients and younger patients