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Amlodipine and Atorvastatin

AMLODIPINE AND ATORVASTATIN

Manufacturer: Bryant Ranch Prepack

Score: 141.0

Quick Summary

Amlodipine and Atorvastatin is a combination drug used to treat hypertension, angina, and hyperlipidemia. It combines a calcium channel blocker (amlodipine) and a HMG-CoA reductase inhibitor (atorvastatin). The drug is indicated for patients with hypertension, coronary artery disease, and hyperlipidemia, and is available in various strengths. Important safety information includes warnings about myopathy, rhabdomyolysis, and liver enzyme abnormalities. Contraindications include active liver disease, pregnancy, and lactation. The recommended dosage is individualized, with initial doses ranging from 5-10 mg for amlodipine and 10-20 mg for atorvastatin. Special population considerations include pregnancy, nursing mothers, pediatric use, and geriatric use.

Key Clinical Findings and Indications

  • Hypertension
  • Angina
  • Hyperlipidemia
  • Coronary Artery Disease

Important Safety Information

Warning

Myopathy and rhabdomyolysis have been reported with atorvastatin, and liver enzyme abnormalities have been reported with both amlodipine and atorvastatin.

Contraindications

  • Active liver disease
  • Pregnancy
  • Lactation

Adverse Reactions

  • Myopathy
  • Rhabdomyolysis
  • Liver enzyme abnormalities
  • Edema
  • Dizziness
  • Fatigue
  • Nausea

Dosing Recommendations

General Guidance

Dose adjustments may be necessary based on individual patient response and tolerance.

Hypertension

Adult Dose

5-10 mg

Pediatric Dose

2.5-5 mg

Angina

Adult Dose

5-10 mg

Pediatric Dose

Not established

Hyperlipidemia

Adult Dose

10-20 mg

Pediatric Dose

10-20 mg

Special Population Considerations

Pregnancy

  • Contraindicated in pregnancy
  • May cause fetal harm

Nursing Mothers

  • Contraindicated in nursing mothers
  • May cause harm to infant

Pediatric Use

  • Safety and efficacy not established in pediatric patients under 6 years of age
  • Dosing recommendations available for pediatric patients 6-17 years of age

Geriatric Use

  • No overall differences in safety and efficacy observed in geriatric patients
  • Dose selection should be cautious in geriatric patients