FUROSEMIDE
Manufacturer: Hikma Pharmaceuticals USA Inc.
Score: 141.0
Furosemide is a loop diuretic used to treat edema associated with heart failure, cirrhosis of the liver, and renal disease, as well as acute pulmonary edema. It works by inhibiting the reabsorption of sodium and chloride in the kidneys, leading to increased urine production. The initial dose for adults is 20-40 mg given intramuscularly or intravenously, with a maximum dose of 80 mg for acute pulmonary edema. Pediatric dosing is 1 mg/kg body weight, with a maximum dose of 6 mg/kg. Furosemide has several important safety considerations, including the risk of ototoxicity, particularly in combination with other medications, and the potential for adverse reactions such as hypotension, electrolyte imbalance, and gastrointestinal disturbances. Special population considerations include use during pregnancy, where furosemide has been shown to be safe, but should be used with caution, and in pediatric and geriatric patients, where dose adjustments may be necessary due to age-related changes in renal function.
Risk of ototoxicity, particularly in combination with other medications
Dose adjustments may be necessary in pediatric and geriatric patients due to age-related changes in renal function
20-40 mg intramuscularly or intravenously
1 mg/kg body weight
40 mg intravenously, with a maximum dose of 80 mg
Not specified