Moexipril Hydrochloride

MOEXIPRIL HYDROCHLORIDE

Manufacturer: Teva Pharmaceuticals USA, Inc.

Score: 147.0

Quick Summary

Moexipril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor used for the treatment of hypertension. It works by inhibiting the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor, thereby reducing blood pressure. The drug is available in tablet form and should be taken once daily, with or without food. However, it is recommended to take it on an empty stomach to minimize the impact of food on its absorption. The initial dose is 7.5 mg, and it can be increased up to 30 mg daily as needed. Moexipril hydrochloride is contraindicated in patients with a history of angioedema related to previous treatment with an ACE inhibitor and in patients who are hypersensitive to the drug. It is also not recommended for use in pregnancy, especially during the second and third trimesters, due to the risk of fetal harm. Special considerations are needed for patients with renal impairment, nursing mothers, pediatric patients, and geriatric patients.

Key Clinical Findings and Indications

Hypertension
Angiotensin-converting enzyme (ACE) inhibitor
Reduces blood pressure by inhibiting the conversion of angiotensin I to angiotensin II

Important Safety Information

Warning

Moexipril hydrochloride can cause fetal harm when used during pregnancy, especially during the second and third trimesters.

Contraindications

History of angioedema related to previous treatment with an ACE inhibitor
Hypersensitivity to the drug

Adverse Reactions

Cough
Dizziness
Diarrhea
Flu syndrome
Fatigue
Pharyngitis
Flushing
Rash
Myalgia

Dosing Recommendations

General Guidance

The dose can be increased up to 30 mg daily as needed, and it should be adjusted according to the patient's blood pressure response.

Hypertension

Adult Dose

7.5 mg once daily, with or without food

Pediatric Dose

Not established

Special Population Considerations

Pregnancy

Moexipril hydrochloride can cause fetal harm when used during pregnancy, especially during the second and third trimesters.
It is recommended to discontinue the drug as soon as possible when pregnancy is detected.

Nursing Mothers

It is not known whether moexipril hydrochloride is excreted in human milk.
Caution should be exercised when the drug is given to a nursing mother.

Pediatric Use

The safety and effectiveness of moexipril hydrochloride in pediatric patients have not been established.
Neonates with a history of in utero exposure to moexipril hydrochloride should be monitored for oliguria and hypotension.

Geriatric Use

Clinical studies did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects.
Dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range.